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Inhibitors of CYP3A4 which include cimetidine and erythromycin are prone to cut down sildenafil clearance. CYP3A4 inducers for example rifampicin may lessen the plasma concentrations of sildenafil. Symptomatic hypotension when employed with α-blockers. Plasma concentrations are increased by ritonavir.

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Alpha-blockers are occasionally prescribed for prostate complications or higher blood pressure level. In certain people, the use of VIAGRA® or generic VIAGRA® with alpha-blockers can cause a fall in hypertension or to fainting